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Cannabinol (CBN): What Is It and Why Is It Getting So Much Attention?

CBN Isolate Bulk, or cannabinol, is a rare cannabinoid found in hemp and cannabis that may aid in sleep and act as an anti-inflammatory, among other things.

Despite the low levels of CBN found in hemp and psychoactive cannabis (“marijuana”), this cannabinoid is gaining popularity.

More and more information about the beneficial effects of cannabinoids appears to be emerging. Today, we’ll look at CBN Isolate Bulk (cannabinol) and why some companies selling CBN are touting it as the next big thing for people suffering from insomnia, glaucoma, and arthritis.

While we love hemp and everything made from it, we also believe in science, and the science of CBN is relatively new. As we’ll see below, there’s still a lack of evidence to back up brands’ claims about the benefits of CBN Isolate Bulk. At the same time, what is known is promising, implying that CBN, like other compounds found in hemp such as CBD or Cannabigerol, can help people feel better (CBG).

What exactly is CBN?

One of the many cannabinoids found in the cannabis or hemp plant is cannabinol. This cannabinoid differs from others in that it is not synthesised from Cannabigerolic acid (CBGA). This cannabinoid is instead made from aged tetrahydrocannabinol (THC). CBN, on the other hand, is a non-intoxicating cannabinoid, unlike THC. It will not make you high.

CBN Isolate Bulk is abundant in older cannabis, but it accounts for less than 1% of the plant’s total content.

Is CBN a sedative? Can CBN aid in the treatment of insomnia?

CBN’s use as a sleep aid is by far its most popular and contentious property. It’s contentious because, while some users (and hemp brands) swear by its sleep aid properties, research is mixed.

One study, conducted in 1975, found that Bulk CBN Isolate had a positive effect on sleep. It did, however, involve the use of CBN in conjunction with THC, the main active ingredient in psychoactive cannabis. The results appeared to show that subjects felt more drowsy when taking THC with CBN, but not significantly different when taking cannabinol alone.

Aside from this single study, there isn’t much evidence to scientifically prove that cannabinol improves sleep.

Steep Hill, a cannabis science and technology company, published a study comparing the effects of CBN Isolate Bulk to the powerful prescription sleep drug diazepam in a CBN sleep aid controversy. However, they recently changed the text to read, “Initially, it was reported that CBN was a promising adjunct in the treatment of insomnia, but with the advent of a few small trials, no sedative qualities were observed.” More research is required.”

At the moment, it appears that CBN may or may not act as a sleep aid. Because of the “entourage effect,” it may work better when combined with other cannabinoids, particularly THC. Until more research is conducted, our readers should give it a shot and see how it goes. Everyone is unique, and what works for one person does not always work for another.

Other advantages of CBN

CBN has been shown to have numerous medicinal properties in preliminary research. Leafly provided the most comprehensive list of this compound’s benefits among the various websites we visited.

One thing you’ll notice about this study is that it’s still in its early stages. Just because something works in a lab or on rats does not guarantee that it will work in humans. Let’s take a look with that in mind.


Cannabinoids’ effectiveness against antibiotic-resistant bacteria was investigated in a 2008 study. Cannabinol showed promise as an antibacterial agent in the lab. It’s worth noting that we still don’t understand the mechanism of action — that is, scientists don’t know how hemp compounds fight bacteria.


Researchers used cannabinol as a treatment for ALS in a rodent study in 2005. They discovered that it could postpone the onset of the condition.

“Further research is needed to determine whether non-psychotropic cannabinoids might be useful in alleviating symptoms in ALS,” the authors write.


CBN was found to increase the amount of food rats ate in yet another rodent study. It’s worth noting that THC, the cannabinoid responsible for the “munchies,” is the precursor to CBN.


CBN may be beneficial to those suffering from glaucoma. In a 2007 rabbit study, CBN (along with THC) reduced intraocular pressure, the most important risk factor for glaucoma.

Before you get too excited, keep in mind that Bulk CBN Isolate was not found to be any more effective than standard glaucoma medications.


CBN, like other cannabinoids, acts as an anti-inflammatory and aids in the treatment of rheumatoid arthritis. It was shown to reduce arthritis symptoms in one rodent study.

CBN Administration

CBN is most commonly consumed as a tincture under the tongue (sublingually). Before swallowing, hold the tincture under your tongue for at least 30 seconds and swish it around your mouth a little. This ensures complete absorption.

The majority of CBN tinctures contain 50-300mg of Bulk CBN Isolate per 30ml (1 ounce) bottle. Many of the tinctures on the market contain a combination of CBN and CBD, usually in the ratio of 1 part CBN Isolate Wholesale to 3 parts CBD. It is also available as a full-spectrum oil in combination with CBD and other cannabinoids.

Although CBD and Wholesale CBN Isolate work well together, especially as a sleep aid and for pain and inflammation management, there is one word of caution when combining these two cannabinoids. While combining them is perfectly safe, they do have opposing benefits. CBD, for example, has a mild appetite suppressant effect, whereas Wholesale CBN Isolate has an appetite stimulant effect. So, depending on your condition, it may be better not to combine them.

This compound is also available in capsule form, specifically designed as a sleep aid. Cannabinol can also be found as an isolate (an odorless, flavorless powder or crystal) or smoked in hemp and cannabis flower.

Dosage recommendations: As with all cannabinoids, we advise you to “start low and go slow.” That means you should start with a low dose of Wholesale CBN Isolate and wait to see how it affects you before increasing.

For example, you could start with a half dropper of tincture before bed and work your way up or down from there to find your optimal dose. When combining Bulk CBN Isolate with other substances that may cause drowsiness or dizziness, exercise caution.

Is it possible for CBN to interact with pharmaceutical drugs?

There are currently no known interactions between Bulk CBN Isolate and medications. This is not to say that things will not change as this compound becomes more popular and studied.

We discussed the possibility of CBD interacting with drugs that carry a “grapefruit warning” in our article on CBD side effects. We don’t know yet whether cannabinol has similar effects.

A study published in Drug Metabolism and Distribution in 2020 looked at the risks of interactions between plant cannabinoids and a drug-metabolizing enzyme called carboxylesterase (CES1). CES1 is required for the activation and deactivation of blood pressure-regulating drugs, as well as the drug Ritalin.

THC, CBD, and Wholesale CBN Isolate all inhibit CES1, according to researchers at the University of Michigan and Florida. However, because of the large amounts required to cause harm, this is probably not cause for concern. For example, they claimed that hundreds of thousands of milligrammes of CBD would be required to cause any harm. Despite the fact that CBN Isolate Wholesale is more potent, the dosage required to interfere with these drugs far exceeds the dosages used by consumers.

As always, consult your doctor before taking this or any other cannabinoid supplement.

A promising natural substance

We hope this article on cannabinol was informative, despite the fact that there is still so much we don’t know.

As previously stated, cannabinoid use affects everyone differently. There is currently no exact science to this. So, while doing your research is important, so is being patient and experimenting with different cannabinoid combinations and dosages until you find what works for you.


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